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For inhalers, another class of drug-device combination products, the median number of patents at FDA approval has steadily increased from 2 (for inhalers approved 1986-1997) to 8 (1998-2008) to 11 (2009-2020), with more than half of these patents covering inhaler delivery devices

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Myocardial injury markers also differed, suggesting that lesion footprint, contact and catheter architecture all contribute to the biological effect