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For many people, the most realistic approach involves either staying on a low maintenance dose of Ozempic indefinitely (treating obesity as the chronic condition it is), accepting that some weight regain is normal and expected while minimizing it through strategic efforts, or being willing to restart treatment if regain exceeds predetermined thresholds

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Sub-chronic administration of liraglutide in rats significantly suppressed weight gain by reducing food intake, and this effect was not affected by deafferentation of subdiaphragmatic vagal afferents [2]