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GLP-1 in addiction medicine: GLP-1 acts on pancreas, gut, kidney, heart and thyroid receptors to activate reward/stress hubs (VTA, NAc, ARC, PFC, hypothalamus). GLP-1 RAs provide sustained central and peripheral GLP-1R activation

Novo Nordisk said in a statement that the study lacked sufficient data to establish an association between semaglutide and NAION, adding that the disorder is “not an adverse drug reaction” for publicly available forms of the drug

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