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Marketed under the brand names Mounjaro (for diabetes) and Zepbound (for weight management in adults with BMI ≥30 kg/m² or ≥27 kg/m² with at least one weight-related comorbidity), tirzepatide represents the first dual incretin receptor agonist available in clinical practice
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The total effect of semaglutide versus placebo was estimated using the same model but without change in body weight (the mediator) included
