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Dapagliflozin was negative in the Ames mutagenicity assay and was positive in a series of in vitro clastogenicity assays in the presence of S9 activation and at concentrations greater than or equal to 100 μg/mL

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While the metabolic efficacy of GLP-1RAs is extensively validated, their potential in neuro-ophthalmology is contingent upon their ability to penetrate the blood-brain barrier (BBB) and the BRB