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GLP1 receptor agonists are supported by preclinical and observational evidence for reducing addictive behaviors, particularly alcohol and nicotine use. Initial randomized clinical trials indicate possible reductions in craving and substance intake, though

This budget impact concern is the primary driver of payer reluctance to cover these medications for obesity, despite their cost-effectiveness at the individual patient level

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Beyond this, there are several other factors that could contribute to increased affordability over the next 5 years: Competition : Other companies like Viking Therapeutics and Altimmune are developing their own GLP-1 drugs