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Semaglutide, marketed as Ozempic, Wegovy, and Rybelsus, is an FDA-approved GLP-1 receptor agonist used for type 2 diabetes and weight management

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Pdx1 is a major regulator of pancreatic organogenesis, β cell maturation and identity preservation, and also has the function of promoting normal insulin secretion (Ebrahim et al., 2022)