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A Key mechanism in SM is the sarcolipin-mediated uncoupling of Sarcoplasmic—Endoplasmic Reticulum Calcium ATPase (SERCA) ( 2+ -cycling in the muscle is triggered by the leakage of Ca 2+ from the sarcoplasmic reticulum via the ryanodine receptor (RYR)1 which subsequently activates SERCA
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[1] [5] The mechanism of action involves several pathways that improve glycemic control and support weight loss
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