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This is most dramatically illustrated through differences in the intake patterns of the same drug with different routes of administration 45,46,47,48,49,50,58 known as the โrate hypothesisโ of addiction 49,59,60
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Bone Microarchitecture Analysis Micro-CT analysis of bones from GLP-1R agonist-treated animals consistently shows preservation or improvement of trabecular microarchitectural parameters: trabecular number, thickness, spacing, and connectivity density