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Significantly, a study published in 2021 in Diabetes, Obesity and Metabolism saw promising results for weight loss with the drug
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20,21 EMPA-REG OUTCOME was not designed to capture amputation risk, so there is currently no head-to-head comparison of amputation risk with empagliflozin versus canagliflozin, and such interpretation is likely not possible owing to multiple factors confounding any comparison between trials
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