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In a 12-week study, animals fed an allulose-rich diet had: Lower body weight gain Improved insulin sensitivity Higher resting GLP-1 levels—even when not eating allulose These findings suggest that allulose could help retrain the body’s metabolic responses over time

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At the cellular level, GLP-1 receptor activation appears to reduce the production of pro-inflammatory cytokines such as tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), and interleukin-1 beta (IL-1β)