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Patients with Hepatic Impairment A single-dose, open-label study was conducted to evaluate the pharmacokinetics of phentermine and topiramate extended-release 15 mg/92 mg in healthy volunteers with normal hepatic function compared with patients with mild (Child-Pugh score 5 to 6) and moderate (Child-Pugh score 7 to 9) hepatic impairment
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The studies paid off, as the National Institute for Health and Care Excellence (NICE) approved semaglutide as a weight-loss treatment in the UK in September 2023 under the brand name Wegovy and at a dosage of up to 2.4mg per week