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However, that study had few GLP-1 receptor agonist users (n=501), leading to an inability to assess self-harm separately and imprecise estimates.8 In a more recent study, semaglutide was found to be strongly associated with a decreased risk of both incident and recurrent suicidal ideation separately among patients with type 2 diabetes and with overweight or obesity (hazard ratios 0.27 (95% CI 0.20 to 0.36) for incident suicidal ideation and 0.44 (0.32 to 0.60)for recurrent suicidal ideation among patients with overweight or obesity
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