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Of note, different reports have also documented the limited efficacy of similar doses of metformin in terms of improvement of metabolic profiles in experimental models of diabetes in female rats 56,57 , as well as in PNA mice 58 , suggesting that the metabolic effects of metformin may be heterogeneous and inconsistent depending on the dose and preclinical model used
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Cardiovascular Benefits Type 2 diabetes is often associated with an increased risk of cardiovascular diseases, including heart attack, stroke, and heart failure
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