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Companies making Ozempic and Mounjaro sued over 'stomach paralysis' claims

Phentermine's mechanism: Sympathomimetic amine structurally similar to amphetamine Stimulates norepinephrine release in the hypothalamus Activates the sympathetic nervous system (fight-or-flight response) Suppresses appetite through central nervous system stimulation Increases metabolic rate modestly (50-100 kcal/day) Raises heart rate by 3-8 bpm on average Raises systolic blood pressure by 2-5 mmHg on average Half-life of 19-24 hours Tirzepatide's mechanism: Dual GLP-1 and GIP receptor agonist Slows gastric emptying, keeping food in the stomach 2-4 hours longer Increases insulin secretion in response to food Suppresses glucagon (which normally raises blood sugar) Acts on satiety centers in the hypothalamus through incretin signaling Reduces appetite through gut-brain axis communication Raises heart rate by 2-6 bpm on average (Jastreboff et al., NEJM 2022) Minimal effect on blood pressure in most patients Half-life of 5 days The mechanisms are distinct

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These shifts in hydration and mineral balance contribute to headache frequency