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The piece lays out a practical framework for turning those signals into pharmacist outreach and member support, with two guardrails I think matter more than the modeling: flags should trigger help rather than coverage restriction, and equity monitoring belongs in the design from the start, not bolted on after

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Desensitization and Receptor Trafficking Most agonist-activated GPCRs undergo rapid desensitization through a coordinated two-step process: first, phosphorylation of the receptor by GRKs, and second, recruitment of β-arrestins to these phosphorylated sites, which sterically block further G-protein coupling [54]