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Each comparison was executed using two different TAR definitions reflecting different causal contrasts (35): intention-to-treat (ITT) TAR, where follow-up was censored at the end of observation, and on-treatment TAR, where follow-up was censored at treatment discontinuation or at escalation with other T2DM agents

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Exendin-4 treatment for 8–12 weeks also reduced atherosclerosis (7, 8) and plaque macrophages (8) in Ldlr –/– mice on a high-cholesterol diet (HCD) (6)