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Phase 2 trial doses ranged from 1 mg to 12 mg once weekly The 12 mg weekly arm produced the greatest average weight loss All participants began at lower doses and escalated gradually Doses are not yet MHRA-licensed and cannot currently be prescribed in the UK Ongoing Phase 3 trials will determine the final approved dosing regimen Understanding the Retatrutide Titration Schedule The titration schedule for retatrutide is one of the most clinically significant aspects of its use