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Nature Metabolism DOI:10.1038/s42255-026-01534-8 Abstract Semaglutide drives weight loss through cAMP-dependent mechanisms in GLP1R-1 expressing hindbrain neurons Glucagon-like peptide 1 receptor (GLP1R) agonists, such as semaglutide, drive weight loss by binding to GLP1Rs—classically described as G s -coupled G-protein-coupled receptors—in the brain
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Retatrutide represents the next evolution in incretin-based therapies for weight management
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