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Unlike sarcopenia, which requires both loss of muscle quantity and reduced function, lean mass reduction is a body-composition outcome most often assessed using dual-energy X-ray absorptiometry (DXA) or bioimpedance analysis (BIA) [2, 20]

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Vascular smooth muscle-specific NKO mice show a dilated aorta, and angiotensin II administration causes intravascular hemorrhage and aortic dissection [77]