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EMPA compared to DPP-4i, was associated with 27-47% lower risk of hospitalization for heart failure (HHF), stroke, all-cause mortality (ACM), and two composite outcomes: HHF plus ACM
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Reports submitted to the FDA Adverse Event Reporting System have included insomnia, anxiety, nervousness, and depressive symptoms, 79 while the European Medicines Agency has flagged cases of depression, self-injury, and suicidal ideation among users of liraglutide or semaglutide
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