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Diabetic Gastroparesis: Principles and Current Trends in Management - PMC

In preclinical efficacy studies in diet-induced obese (DIO) mice and obese monkeys, treatment with AMG133 reduces body weight and improves metabolic parameters to a larger extent than a GLP-1 receptor agonist alone (84), while, at this time, phase 2 data have only been disclosed through a company announcement with headline results (85)

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Llewellyn-Smith IJ, Gnanamanickam GJ, Reimann F, Gribble FM, Trapp S