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Novo Nordisk, the makers of Ozempic and Wegovy, that has a significant share of the global market for insulin and obesity treatments acknowledge the challenges in developing an oral GLP-1 drug
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Interestingly, the concomitant administration of GLP-1 receptor agonists with a sulphonylurea in the in situ perfused rat pancreas led to uncoupling of the insulinotropic effect of GLP-1 from its glucose dependence [136]
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