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in Spain, its current prevalence ranges between 28โ33%11,12 and it is a recognized as a cardiovascular risk factor and increases the mortality in this population.13โ15 Furthermore, in patients with DM2 and advanced CKD there are limitations in the prescription of certain antihyperglycemic drugs (e.g., metformin or sulfonylureas) and there is an increased risk of hypoglycemia with antihyperglycemic treatment,16 a complication that is associated with increased cardiovascular risk17 and hinders the achievement of glycemic control targets
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Despite this apparent difference in magnitude, the test for subgroup differences was not statistically significant ( p = 0.36), indicating that both agents may effectively reduce systolic blood pressure, without a superior drug
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