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While on GLP-1 medications, the brain regions responsible for hunger signaling, particularly the hypothalamus and brainstem, adapt to consistently elevated GLP-1 receptor activation
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Localized reactions have been reported in patients using liraglutide and dulaglutide [43–46], while generalized urticaria and systemic anaphylaxis have been associated with exenatide and tirzepatide [47–51]
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