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However, nearly 80% of included reviews were of critically low quality (AMSTAR 2) and there was moderate-to-high evidence overlap (CCA 10.47%), which fundamentally limits the confidence in these findings
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![Structures of (a) GLP-1, (b) GIP and (c) tirzepatide [19, 88, 90]](https://www.researchgate.net/publication/370926483/figure/fig4/AS:11431281185432337@1693619320519/Structures-of-a-GLP-1-b-GIP-and-c-tirzepatide-19-88-90-Amino-acids-are.png)
