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As canagliflozin and acarbose have been shown to increase lifespan in mice, we investigated the effect of sodium-glucose cotransporter 2 (SGLT2) inhibitor, α-glucosidase inhibitor or both on the cellular senescence of β-cells in a T2DM mouse model

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Despite their clinical effectiveness and the volume they represent in the market, real-world use of GLP-1s is heavily influenced by non-clinical factors such as drug availability, insurance coverage, and formulary decisions ( 5 , 6 )