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Figure 1 Figure 2 The discovery of the second incretin, GLP-1, originated from observations in 1982 that anglerfish proglucagon mRNA contained coding sequences of glucagon-related peptide, flanked by pairs of basic amino acids characteristic of the sites cleaved during post-translational processing of prohormones ( Figure 1 – Section A]
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2024;404(10586) Krumholz HM, de Lemos JA, Sattar N, et al
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