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There are specific circumstances in which professional advice is particularly important: Before starting any new supplement whilst enrolled in a clinical trial or taking a GLP-1 medicine, as this may affect trial validity or treatment safety If you have diabetes , as retatrutide has glucose-lowering properties and, if you are also taking insulin or a sulfonylurea, the risk of hypoglycaemia requires careful management If you have liver or kidney disease , since both NAD+ metabolism and retatrutide's glucagon-mediated actions involve hepatic pathways