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But besides simply not pooping regularly, constipation from semaglutide and other GLP-1 medications can present as: Fewer than three bowel movements per week Hard, dry, or lumpy stools Straining during bowel movements Feeling of incomplete evacuation Abdominal discomfort or bloating Hard stool followed by watery loose stool It’s important to distinguish between occasional constipation (which is common) and chronic constipation , which may require assistance to address the cause

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Semaglutide is the active ingredient in Ozempic (FDA-approved for type 2 diabetes) and Wegovy (FDA-approved for chronic weight management)