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37 , 40 Concomitantly, circulating pro‐inflammatory cytokines such as tumour necrosis factor‐α (TNF‐α), interleukin‐6 (IL‐6), and interleukin‐1β (IL‐1β) can cross the blood–brain barrier (BBB) or alter its integrity, thereby promoting microglial activation and astrocytic reactivity
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Deshmukh, V