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The definitive impact of tirzepatide on cardiovascular disease will be addressed in the ongoing SURPASS-COVT study (ClinicalTrials.gov number, NCT04255433), which compares tirzepatide with dulaglutide in patients with T2DM and ASCVD

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The pathological hallmarks of DKD include glomerulosclerosis, tubulointerstitial fibrosis, and thickening of the glomerular basement membrane [187]