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Retatrutide: A Promising Breakthrough for Fatty Liver Disease
doi: 10.1016/j.dsx.2020.02.012
Mature (Skin type)
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AMPK also phosphorylates SREBP-1c, which inhibits proteolytic maturation, nuclear translocation of SREBP-1c, and the expression of the downstream fatty acid synthase gene, thus increasing fatty acid β-oxidation and reducing the de novo synthesis of triglycerides (TG) [33] and their liver accumulation, finally preventing hepatocyte steatosis [34] (Figure 1)
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