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The proinflammatory cytokines, such as interleukin-1 beta (IL-1 β ), interferon gamma (IFN- γ ), and tumor necrosis factor alpha (TNF- α ), inhibit glucose-stimulated insulin secretion and proliferation of beta-cells [40–42]
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Conclusion In summary, the collective evidence from various studies, including those exploring dual agonists (GLP-1R/GIPR) and tri-agonists (GLP-1R/GIPR/GCGR), demonstrates unprecedented improvements in diabetes and body weight compared to GLP-1RA treatment alone