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Initiation of SGLT2i During the Trial In analyses of the primary outcome among participants who reported SGLT2i use at baseline or initiated SGLT2i during the study (n=2168 for oral semaglutide and n=2550 for placebo), there were 250 MACE events (11.5%) in the semaglutide group and 326 MACE events (12.8%) in the placebo group, generating an HR of 0.89 (95% CI, 0.76–1.05
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