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Their closure leads to the depolarization of the cell, which opens voltage-dependent calcium (Ca V ) channels, triggering the action potential that allows insulin granules to be released from the pancreas ( + (BK) and voltage-gated potassium (K V 2.1 and K V 1.7) channels ( V 2.1 channels, was isolated from the venom of the Chilean pink tarantula, Grammostola rosea (Swartz and MacKinnon, 1995)