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How GLP-1 Receptor Agonists Work Native GLP-1 has a short half-life of just 1-2 minutes because it is rapidly broken down in the blood by the enzyme dipeptidyl peptidase 4 (DPP-4)
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In a second study, the procedure above was repeated but with chymotrypsin as the protease (instead of trypsin) and with glutaryl-L-phenylalanine 4-methyl-7-coumarinylamide as the substrate, and a dose response curve with chenodeoxycholate at different concentrations was constructed
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