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Likewise, the average change in FPG through the trial was −37.89 mg/dl (95% CI −52.88 to −22.89 mg/dl) and −35.57 mg/dl (95% CI −48.07 to −23.06 mg/dl) for free up-titration and FRC, respectively, causing insignificant difference (WMD −2.29 mg/dl, 95% CI −45.07 to 40.49 mg/dl